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Immunometabolism in Autoimmune Diseases

Dear Colleagues,

Autoimmunity is caused by dysregulated immune cells that are sustained by alterations of their cellular metabolism. Disease-specific and cell-specific metabolic alterations have been uncovered in several mouse models of autoimmune disease as well as in some human autoimmune diseases. Importantly, targeting the aberrant immune cell metabolism with specific inhibitors has shown therapeutic efficacy in several pre-clinical models as well as in small cohorts of patients with autoimmune diseases. These promising results suggest that metabolic inhibitors could be used, either alone or in combination with existing therapies, for a more effective and may be more selective treatments of autoimmune diseases. Significant advances toward this goal will require a combination of basic mechanistic studies to dissect metabolic alterations in the major immune effector cells for each autoimmune disease, and pre-clinical studies and evaluate the safety, efficacy and specificity of the corresponding metabolic inhibitors. This special issue of Immunometabolism aims to provide a series of articles covering all aspects of how immunometabolism impacts upon autoimmune diseases, and how it can be used for therapeutic purposes.

Professor Laurence Morel

Guest Editor

Keywords

Immunometabolism

Autoimmunity

Glycolysis

Oxidative stress

mTOR

Metabolic Reprogramming

Metabolic inhibitors

T Cells

B cells

Regulatory T-Lymphocytes

Pre-clinical models

Submission Deadline: 15 January 2020

Online Submission

Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Immunometabolism and then gathered together on the special issue webpage. We welcome Research articles, Review papers and Short Communications. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.



Note

Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.

All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.

Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.

Guest Editor

  • Professor Laurence Morel

    University of Florida

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