Aging of the immune system is characterized by loss of function of adaptive immunity, and increase in non-specific innate immune activation (Inflammaging). These changes are driven by alterations in level and composition of circulating factors, alterations in structure and function of lymphoid organs, and intrinsic changes in immune cells. Studies in recent years highlight cellular metabolic pathways and metabolite availability as key regulators of immune cells activation and effector functions. However, it is unknown how these pathways are conserved with aging, and what is their contribution to immune dysfunction in the elderly. In this special issue of Immunometabolism we are welcoming studies looking into how changes in cellular and systemic metabolism are contributing to immune dysfunction in the elderly. We are looking for papers covering both adaptive and innate immune components, and are welcoming submissions of both original research articles and review articles related to these topics.
Professor Noga Ron-Harel
Age-related immune dysfunction
Genetic models of frailty
Genetic models of mitochondrial dysfunction and accelerated aging
Submission Deadline: 15 April 2020
Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Immunometabolism and then gathered together on the special issue webpage. We welcome Research articles, Review papers and Short Communications. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.
All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.
Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.
Technion-Israel Institute of Technology